DTRs

Sample Size and Timepoint Tradeoffs for Comparing Dynamic Treatment Regimens in a Longitudinal SMART

Clinical practice often involves delivering a sequence of treatments which adapts to a patient’s changing needs. A dynamic treatment regimen (DTR) is a sequence of pre-specified decision rules which, based on a patient’s ongoing data, recommend …

Sample Size Considerations for Comparing Dynamic Treatment Regimens in a Sequential Multiple-Assignment Randomized Trial with a Continuous Longitudinal Outcome

Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence of treatments or …

Design and Analysis Considerations for Comparing Dynamic Treatment Regimens with Binary Outcomes from Sequential Multiple Assignment Randomized Trials

In behavioral, educational and medical practice, interventions are often personalized over time using strategies that are based on individual behaviors and characteristics and changes in symptoms, severity, or adherence that are a result of one's …